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                                         The SAS System      11:23 Saturday, October 21, 2000   1

                                     The LOGISTIC Procedure

                                        Model Information

                         Data Set                       WORK.DOSE
                         Response Variable (Events)     Deaths
                         Response Variable (Trials)     Total
                         Number of Observations         6
                         Link Function                  Logit
                         Optimization Technique         Fisher's scoring


                                         Response Profile

                                Ordered     Binary           Total
                                  Value     Outcome      Frequency

                                      1     Event                3
                                      2     Nonevent            15


                                    Model Convergence Status

                         Convergence criterion (GCONV=1E-8) satisfied.


                                      Model Fit Statistics

                                                           Intercept
                                            Intercept         and
                             Criterion        Only        Covariates

                             AIC               18.220         12.072
                             SC                19.111         13.853
                             -2 Log L          16.220          8.072


                             Testing Global Null Hypothesis: BETA=0

                     Test                 Chi-Square       DF     Pr > ChiSq

                     Likelihood Ratio         8.1478        1         0.0043
                     Score                    5.7943        1         0.0161
                     Wald                     2.7249        1         0.0988


                                         The SAS System      11:23 Saturday, October 21, 2000   2

                                     The LOGISTIC Procedure

                            Analysis of Maximum Likelihood Estimates

                                              Standard
               Parameter    DF    Estimate       Error    Chi-Square    Pr > ChiSq

               Intercept     1     -9.4745      5.5677        2.8958        0.0888
               Dose          1      2.0804      1.2603        2.7249        0.0988


                                      Odds Ratio Estimates

                                        Point          95% Wald
                           Effect    Estimate      Confidence Limits

                           Dose         8.007       0.677      94.679


                  Association of Predicted Probabilities and Observed Responses

                        Percent Concordant     88.9    Somers' D    0.867
                        Percent Discordant      2.2    Gamma        0.951
                        Percent Tied            8.9    Tau-a        0.255
                        Pairs                    45    c            0.933
                                         The SAS System      11:23 Saturday, October 21, 2000   3

                                     The LOGISTIC Procedure

                                   Exact Conditional Analysis

                                    Conditional Exact Tests

                                                          --- p-Value ---
                       Effect   Test          Statistic    Exact      Mid

                       Dose     Score           5.4724    0.0245   0.0190
                                Probability     0.0110    0.0245   0.0190


                                    Exact Parameter Estimates

                                                 95% Confidence
                    Parameter    Estimate            Limits           p-Value

                    Dose           1.7999       0.1157      5.8665     0.0245


                                       Exact Odds Ratios

                                                95% Confidence
                     Parameter   Estimate           Limits          p-Value

                     Dose           6.049       1.123    353.000     0.0245